Checkpoint Inhibitors Side Effects

The most common side effects of checkpoint inhibitors are.

Checkpoint inhibitors side effects.

Fatigue weakness nausea confusion headache loss of appetite vision problems fever. Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections. After about six months of therapy john tells you that over the past four weeks he has been experiencing increased fatigue weight gain insomnia and constipation. Common side effects of immune checkpoint inhibitors include.

Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening. Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies. He says he figures these are just normal side effects of his medication.

Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss. Paying careful attention to potential symptoms is therefore crucial. Other immune checkpoint inhibitors are under clinical evaluation. Besides headache dizziness and apathy ataxia tremor paralysis myoclonus cognitive impairment speech disorders and even seizures may occur.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors.